Impact of colonoscopy on health-related quality of life: findings from the RECEDE study

Andronis, L.; Waugh, N.; Zanganeh, M.; Krishnamoorthy, A.; Parsons, N.; Hull, M.; Wheatstone, P.; Arasaradnam, R. P.

doi:10.1186/s12955-024-02262-x

Health and Quality of Life Outcomes

Table 3 EQ-5D values by respondents’ demographic characteristics

From: Impact of colonoscopy on health-related quality of life: findings from the RECEDE study

	N	T1		T2		T3		Diff (T2 – T1)		Diff (T2 – T3)
EQ-5D-5 L index values		Mean	SD	Mean	SD	Mean	SD	Mean	p-value^a	Mean	p-value^a
Age group
20–39	17	0.732	0.164	0.678	0.244	0.791	0.145	-0.054	0.105	0.113	0.027*
40–59	101	0.761	0.229	0.726	0.220	0.784	0.224	-0.034	0.012*	0.058	0.000***
60–79	147	0.759	0.211	0.730	0.232	0.799	0.218	-0.029	0.001***	0.069	0.000***
over 80	6	0.852	0.130	0.803	0.173	0.835	0.112	-0.049	0.088	0.032	0.556
Sex
Female	142	0.708	0.251	0.662	0.257	0.736	0.255	-0.046	0.000***	0.074	0.000***
Male	129	0.817	0.144	0.798	0.162	0.857	0.130	-0.019	0.026*	0.059	0.000***
Ethnicity
White British	256	0.756	0.117	0.722	0.160	0.791	0.113	-0.035	0.000***	0.069	0.000***
Other ethnicity	15	0.822	0.218	0.816	0.229	0.839	0.218	-0.006	0.803	0.023	0.528
BMI group
Healthy weight	78	0.778	0.182	0.753	0.203	0.829	0.189	-0.026	0.067	0.077	0.000***
Underweight	1	0.893	n/a	0.793	n/a	0.793	n/a	-0.101	n/a	0.000	n/a
Overweight	113	0.787	0.216	0.756	0.217	0.811	0.213	-0.030	0.012*	0.054	0.000***
Obese	79	0.702	0.230	0.658	0.251	0.735	0.229	-0.043	0.000***	0.076	0.000***
Alcohol drinking
Alcohol drinker	168	0.792	0.189	0.761	0.191	0.823	0.191	-0.031	0.001***	0.062	0.000***
Non-drinker	103	0.708	0.241	0.671	0.267	0.746	0.240	-0.037	0.001***	0.075	0.000***
Smoking
Non-smoker	182	0.771	0.193	0.734	0.212	0.806	0.194	-0.037	0.000***	0.072	0.000***
Former Smoker	61	0.804	0.166	0.765	0.176	0.819	0.185	-0.039	0.009**	0.054	0.000***
Current Smoker	28	0.589	0.332	0.596	0.351	0.657	0.327	0.008	0.827	0.061	0.047*
Cigarettes per day^b
1 to 9	20	0.664	0.371	0.683	0.324	0.741	0.328	0.018	0.669	0.059	0.041*
10 to 19	40	0.733	0.218	0.688	0.254	0.745	0.244	-0.046	0.028*	0.057	0.01*
20 to 29	22	0.748	0.179	0.727	0.204	0.779	0.192	-0.021	0.062	0.052	0.059
More than 30	7	0.926	0.059	0.890	0.106	0.942	0.080	-0.035	0.000***	0.052	0.225
Abdominal mass
None	268	0.760	0.215	0.727	0.227	0.794	0.215	-0.032	0.000***	0.067	0.000***
Definite	2	0.856	0.017	0.798	0.017	0.795	0.003	-0.058	0.250	-0.003	0.868
Definite and tender	1	0.673	n/a	0.483	n/a	0.755	n/a	-0.190	n/a	0.272	n/a
Instances of liquid stool passing per day
None	98	0.795	0.230	0.762	0.246	0.817	0.237	-0.034	0.002**	0.055	0.000***
1 to 3	75	0.794	0.150	0.772	0.157	0.843	0.123	-0.022	0.072	0.071	0.000***
4 to 5	46	0.729	0.183	0.704	0.179	0.761	0.193	-0.025	0.140	0.057	0.003**
6 or more	52	0.671	0.256	0.618	0.275	0.709	0.259	-0.054	0.013*	0.091	0.001**
Blood in stools
None	140	0.742	0.231	0.716	0.247	0.771	0.229	-0.026	0.003**	0.055	0.000*
Streaks of blood with stools in less than half of cases	34	0.811	0.156	0.773	0.164	0.806	0.203	-0.038	0.071	0.034	0.109*
Obvious blood with most of stools	29	0.780	0.173	0.752	0.192	0.807	0.221	-0.028	0.122	0.056	0.090*
Blood alone passes	68	0.762	0.215	0.715	0.224	0.828	0.180	-0.047	0.012*	0.113	0.000*
Anaemia
No	216	0.769	0.182	0.728	0.205	0.804	0.192	-0.041	0.000***	0.076	0.000***
Yes	55	0.726	0.309	0.724	0.299	0.755	0.283	-0.002	0.883	0.031	0.018*
Colonoscopy findings
No SBD (not life-threatening condition, no immediate action needed) ^d	227	0.751	0.222	0.720	0.236	0.794	0.223	-0.031	0.000***	0.074	0.000***
SBD (not life-threatening condition, immediate action needed)^e	34	0.825	0.152	0.781	0.156	0.817	0.124	-0.044	0.049*	0.036	0.094
SBD (life-threatening condition, urgent action needed)^f	10	0.738	0.164	0.696	0.200	0.709	0.235	-0.042	0.089	0.014	0.623

SBD: severe bowel disease
^a P-values derived from paired t-test for null hypothesis of difference in mean EQ-5D-5 L T1 = EQ-5D-5 L T2 and mean EQ-5D-5 L T2 = EQ-5D-5 L T3. * P-value ≤ 0.05; **p-value ≤ 0.01; *** p-value ≤ 0.001.
^bQuestion answered by former smokers (n = 61) and current smokers (n = 28)
^c Value unavailable owing to small number of observations
^d Defined as colonoscopy results showing no indications of Crohn’s disease or ulcerative colitis, or polyps < 10 mm
^e Defined as colonoscopy results showing mild or moderate Crohn’s disease or ulcerative colitis, or polyps > 10 mm
^f Defined as colonoscopy results showing presence of cancerous lesion, severe Crohn’s disease or severe ulcerative colitis

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ISSN: 1477-7525

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