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Table 6 known-group validity of the EQ-5D-Y-3 L, PROMIS-25, and PedsQL

From: Measurement properties of the EQ-5D-Y-3L, PedsQL 4.0, and PROMIS-25 Profile v2.0 in pediatric patients with spinal muscular atrophy

 

N

EQ-5D-Y-3 L

Index value

EQ VAS

PedsQL 4.0

Overall score

PROMIS-25

Level sum score

Mobile ability due to the use of wheelchair

     

No

94

0.57 (0.18)

56.6 (22.4)

32.2 (17.5)

57.8 (10.7)

Use some time

118

0.50 (0.13)

54.9 (22.4)

30.0 (11.8)

59.1 (10.8)

Use all the time

127

0.45 (0.13)

53.3 (27.3)

28.7 (12.3)

59.0 (12.0)

F-statistic

 

18.45

0.5

5.6

0.4

p-value

 

< 0.001

0.6

0.004

0.65

Eta squared

 

0.1

0.003

0.03

0.002

Use of airway cleaning

     

No

274

0.54 (0.18)

56.7 (24.2)

31.7 (15.0)

58.8 (11.0)

Yes

89

0.46 (0.14)

51.8 (25.8)

24.2 (11.9)

59.0 (12.0)

F-statistic

 

16.91

2.6

18.1

0.02

p-value

 

< 0.001

0.12

< 0.001

0.89

Cohen’s D

 

0.5

0.2

0.52

0.02

Scoliosis

     

No

64

0.64 (0.20)

64.4 (23.3)

39.0 (16.7)

29.1 (10.3)

Yes

213

0.49 (0.15)

53.2 (24.4)

27.2 (14.5)

58.3 (11.6)

F-statistic

 

20.03

5.7

18.3

2.5

p-value

 

< 0.001

0.004

< 0.001

0.09

Cohen’s D

 

0.91

0.46

0.86

0.08

Hold up head without support

     

No

41

0.45 (0.13)

39.9 (24.2)

22.4 (13.1)

58.5 (12.7)

Yes

322

0.53 (0.17)

57.5 (24.0)

30.8 (14.6)

58.9 (11.0)

F-statistic

 

8.72

19.5

12.4

0.05

p-value

 

0.003

< 0.001

0.02

0.82

Cohen’s D

 

0.49

0.73

0.58

0.04

Roll over to lateral position

     

No

176

0.45 (0.11)

51.0 (25.3)

24.5 (12.1)

58.7 (12.1)

Yes

187

0.59 (0.19)

59.7 (23.3)

34.8 (15.1)

59.1 (10.3)

F-statistic

 

68.21

11.6

51.1

0.1

p-value

 

< 0.001

0.001

< 0.001

0.71

Cohen’s D

 

0.87

0.36

0.75

0.04

Sit up without support

     

No

130

0.44 (0.12)

48.6 (26.1)

23.3 (12.0)

58.2 (11.8)

Yes

233

0.57 (0.18)

59.3 (22.9)

33.5 (14.7)

59.3 (10.9)

F-statistic

 

47.56

16.5

45.0

0.7

p-value

 

< 0.001

< 0.001

< 0.001

0.41

Cohen’s D

 

1.67

0.44

1.18

0.06

Four-point crawl

     

No

291

0.48 (0.13)

53.4 (24.7)

26.7 (12.1)

58.8 (11.4)

Yes

72

0.72 (0.19)

64.0 (17.7)

42.4 (17.1)

59.4 (10.5)

F-statistic

 

161.35

11.0

80.6

0.2

p-value

 

< 0.001

0.001

< 0.001

0.66

Cohen’s D

     

Stand up without support

     

No

262

0.46 (0.12)

53.3 (25.6)

26.3 (12.5)

58.9 (11.6)

Yes

101

0.68 (0.20)

61.2 (21.1)

39.0 (15.8)

58.9 (10.2)

F-statistic

 

174.4

7.6

63.8

0.001

p-value

 

< 0.001

0.006

< 0.001

0.97

Cohen’s D

 

1.55

0.32

0.94

0.08

Stand alone without support

     

No

286

0.47 (0.12)

53.4 (25.1)

26.7 (12.7)

58.6 (11.5)

Yes

77

0.74 (0.16)

63.3 (21.3)

41.6 (15.4)

60.2 (10.0)

F-statistic

 

252.81

10.2

75.8

1.2

p-value

 

< 0.001

0.002

< 0.001

0.27

Cohen’s D

 

2.04

0.41

0.51

0.05

Walk without support

     

No

278

0.46 (0.12)

53.4 (25.4)

26.7 (12.8)

58.8 (11.5)

Yes

85

0.72 (0.18)

62.2 (20.7)

40.1 (15.6)

59.2 (10.2)

F-statistic

 

220.66

8.3

64.2

0.1

p-value

 

< 0.001

0.004

< 0.001

0.75

Cohen’s D

 

1.84

0.36

0.44

0.05

Walk alone without support

     

No

297

0.47 (0.13)

53.5 (24.9)

27.0 (12.7)

28.6 (11.4)

Yes

66

0.77 (0.15)

64.6 (21.2)

42.7(16.0)

60.4 (10.4)

F-statistic

 

278.8

11.3

75.0

1.5

p-value

 

< 0.001

0.001

< 0.001

0.22

Cohen’s D

 

2.27

0.46

0.57

0.06

Walk 10 m on their own

     

No

304

0.48 (0.13)

53.7 (24.9)

27.1 (12.7)

58.5 (11.4)

Yes

59

0.77 (0.16)

64.9 (20.6)

43.8 (16.0)

60.8 (10.2)

F-statistic

 

234.61

10.6

77.4

2.0

p-value

 

< 0.001

0.001

< 0.001

0.15

Cohen’s D

 

2.18

0.46

0.55

0.09

Go upstairs independently

     

No

334

0.50 (0.15)

54.5 (24.6)

28.2 (12.9)

59.0 (11.3)

Yes

29

0.81 (0.19)

67.2 (22.2)

48.5 (19.9)

58.2 (9.8)

F-statistic

 

109.47

7.3

59.8

0.1

p-value

 

< 0.001

0.007

< 0.001

0.72

Cohen’s D

 

2.03

0.52

0.94

0.22

have bimanual useful function

     

No

73

0.42 (0.14)

45.8 (27.4)

26.0 (13.5)

59.5 (11.7)

Yes

290

0.55 (0.17)

57.9 (21.3)

30.8 (14.8)

58,7 (11.1)

F-statistic

 

35.43

14.7

6.3

0.3

p-value

 

< 0.001

< 0.001

0.01

0.58

Cohen’s D

 

0.78

0.5

0.18

0.11

Raise hands over head when sitting

     

No

218

0.46 (0.13)

51.6 (25.7)

24.7 (11.8)

59.3 (11.8)

Yes

145

0.63 (0.18)

61.3 (21.7)

37.5 (15.2)

58.3 (10.2)

F-statistic

 

108.38

14.0

80.5

0.8

p-value

 

< 0.001

< 0.001

< 0.001

0.38

Cohen’s D

 

1.12

0.4

0.47

0.15

Touch mouths while sitting

     

No

65

0.45 (0.13)

47.7 (27.6)

23.6 (11.4)

56.8 (13.1)

Yes

298

0.54 (0.18)

57.2 (23.7)

31.2 (14.9)

59.3 (10.7)

F-statistic

 

14.90

8.1

14.7

2.7

p-value

 

< 0.001

0.005

< 0.001

0.10

Cohen’s D

 

0.53

0.19

0.39

0.03

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Health and Quality of Life Outcomes

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