Table 1 Patient characteristics
Haemophilia severity | ||||||
|---|---|---|---|---|---|---|
Mild | Moderate | Severe | All | |||
n = 64 | n = 96 | n = 221 | n = 381 | |||
Mean age, years | 34.8 ± 14.8 | 36.2 ± 15.3 | 35.8 ± 13.9 | 35.7 ± 14.40 | ||
18–25 | 21 (32.8%) | 30 (31.3%) | 69 (31.2%) | 120 (31.5%) | ||
26–35 | 16 (25.0%) | 26 (27.1%) | 54 (24.4%) | 96 (25.2%) | ||
36–50 | 18 (28.1%) | 24 (25.0%) | 65 (29.4%) | 107 (28.1%) | ||
51–65 | 5 (7.8%) | 8 (8.3%) | 27 (12.2%) | 40 (10.5%) | ||
66+ | 4 (6.3%) | 8 (8.3%) | 6 (2.7%) | 18 (4.7%) | ||
Country | ||||||
Germany | 3 (4.7%) | 9 (9.4%) | 15 (6.8%) | 27 (7.1%) | ||
Spain | 15 (23.4%) | 28 (29.2%) | 69 (31.2%) | 112 (29.4%) | ||
France | 18 (28.1%) | 19 (19.8%) | 29 (13.1%) | 66 (17.3%) | ||
Italy | 19 (29.7%) | 24 (25.0%) | 78 (35.3%) | 121 (31.8%) | ||
United Kingdom | 9 (14.1%) | 16 (16.7%) | 30 (13.6%) | 55 (14.4%) | ||
BMI | 23.9 ± 2.3 | 24.9 ± 2.9 | 24.7 ± 2.5 | 24.6 ± 2.5 | ||
Employment statusa | ||||||
Employed | 40 (62.5%) | 46 (47.9%) | 120 (55.3%) | 206 (54.9%) | ||
Not employed due to HA | 1 (1.6%) | 3 (3.1%) | 14 (6.5%) | 18 (4.8%) | ||
Not employed – other | 8 (12.9%) | 23 (24.0%) | 37 (17.1%) | 68 (18.1%) | ||
Student | 13 (21.0%) | 17 (17.7%) | 36 (16.6%) | 66 (17.6%) | ||
Other | 0 (0%) | 7 (7.3%) | 10 (4.6%) | 17 (4.5%) | ||
ABR (median, IQR) | 1.16 ± 0.91 (1, 2) | 2.19 ± 3.22 (1, 2) | 3.78 ± 2.99 (3, 3) | 2.94 ± 3.00 (2, 3) | ||
Problem joints (median, IQR) | 0.17 ± 0.42 (0, 0) | 0.52 ± 0.96 (0, 1) | 0.77 ± 1.03 (0, 1) | 0.61 ± 0.96 (0, 1) | ||
Number of problem joints | ||||||
0 | 54 (84.4%) | 65 (67.7%) | 117 (52.9%) | 236 (61.9%) | ||
1 | 9 (14.1%) | 19 (7.3%) | 60 (27.1%) | 88 (23.1%) | ||
2 | 1 (1.6%) | 8 (8.3%) | 29 (13.1%) | 38 (10.0%) | ||
3+ | 0 (0%) | 4 (4.2%) | 15 (6.8%) | 19 (5.0%) | ||
Treatment regimen | ||||||
LTP | 0 (0%) | 0 (0%) | 145 (65.6%) | 145 (38.1%) | ||
Chronic pain | ||||||
None | 39 (60.9%) | 34 (35.4%) | 45 (21.7%) | 121 (37.8%) | ||
Mild | 23 (35.9%) | 43 (44.8%) | 82 (37.1%) | 148 (38.8%) | ||
Moderate | 2 (3.0%) | 18 (18.8%) | 74 (33.5%) | 94 (24.7%) | ||
Severe | 0 (0%) | 1 (1.0%) | 17 (7.7%) | 18 (4.7%) | ||
EQ-5D-5 L index score (median, IQR) | 0.85 ± 0.20 (0.89, 0.18) | 0.78 ± 0.18 (0.68, 0.26) | 0.67 ± 0.26 (0.68, 0.36) | 0.73 ± 0.24 (0.75, 0.35) | ||
EQ-5D-5 L dimension scores | ||||||
Mobility | 1.34 ± 0.70 | 1.58 ± 0.71 | 2.02 ± 0.98 | 1.80 ± 0.91 | ||
Self-care | 1.25 ± 0.67 | 1.40 ± 0.70 | 1.69 ± 0.87 | 1.54 ± 0.82 | ||
Usual activities | 1.27 ± 0.62 | 1.51 ± 0.70 | 1.95 ± 0.94 | 1.73 ± 0.88 | ||
Pain/discomfort | 1.50 ± 0.69 | 1.80 ± 0.78 | 2.17 ± 0.96 | 1.96 ± 0.91 | ||
Anxiety/depression | 1.52 ± 0.84 | 1.56 ± 0.63 | 1.91 ± 0.89 | 1.76 ± 0.84 | ||
EQ-VAS (median, IQR) | 80.65 ± 15.57 (80, 25) | 78.0 ± 14.51 (80, 20) | 66.81 ± 19.29 (70, 24) | 71.93 ± 18.60 (75, 25) | ||