Table 1 Health states with comparable utility estimates to published US DMD utility estimates (Analysis One)
From: Cataloging health state utility estimates for Duchenne muscular dystrophy and related conditions
DMD health state | Existing utility4 | Utility range | Most common health states |
|---|---|---|---|
EA | 0.73 | 0.70–0.76 | • Myocardial infarctiona (n = 31, µ = 0.74, IQR = 0.72–0.76) • Coronary heart disease (n = 29, µ = 0.75, IQR = 0.73–0.76) • COPDb (n = 28, µ = 0.75, IQR = 0.74–0.76) • Locoregional breast cancer (n = 22, µ = 0.73, IQR = 0.70–0.75) • Type 2 diabetes (n = 21, µ = 0.73, IQR = 0.72–0.75) • Liver transplant (n = 24, µ = 0.71, IQR = 0.70–0.71) • Strokec (n = 33, µ = 0.73, IQR = 0.71–0.75) • Compensated cirrhosis (n = 17, µ = 0.73, IQR = 0.70–0.75) • Hepatocellular carcinoma (n = 16, µ = 0.72, IQR = 0.72–0.73) • Suicidal thoughts, consulted helpline (n = 14, µ = 0.73, IQR = 0.71–0.74) |
LA | 0.64 | 0.61–0.67 | • Non-small cell lung cancer (n = 42, µ = 0.64, IQR = 0.62–0.65) • End-stage renal disease (n = 29, µ = 0.63, IQR = 0.61–0.64) • Stroked (n = 26, µ = 0.63, IQR = 0.62–0.64) • Hip fracture (n = 23, µ = 0.64, IQR = 0.63–0.66) • Dialysise (n = 21, µ = 0.64, IQR = 0.62–0.65) • Heart failure (n = 19, µ = 0.64, IQR = 0.62–0.66) • Myocardial infarction (n = 16, µ = 0.64, IQR = 0.62–0.65) • Vertebral fracture (n = 15, µ = 0.64, IQR = 0.63–0.65) • Type 2 diabetes (n = 12, µ = 0.65, IQR = 0.64–0.66) • Ovarian cancer (n = 8, µ = 0.64, IQR = 0.63–0.65) |
ENA | 0.21 | 0.18–0.24 | • Severe stroke (n = 20, µ = 0.20, IQR = 0.20–0.21) • Chronic liver disease (n = 8, µ = 0.2, IQR = 0.20–0.20) • Expanded disability status scale ≥ 4 (n = 8, µ = 0.20, IQR = 0.18–0.21) • Terminal breast cancer (n = 6, µ = 0.21, IQR = 0.19–0.23) • Heart failure (n = 5, µ = 0.20, IQR = 0.19–0.21) • Hepatocellular carcinoma (n = 5, µ = 0.21, IQR = 0.20–0.23) • Migraine (n = 3, µ = 0.21, IQR = 0.20–0.22) • Arthritis progression (n = 3, µ = 0.21, IQR = 0.20–0.22) • Moderate Alzheimer’s disease (n = 3, µ = 0.19, IQR = 0.18–0.20) • Hoehn & Yahr stage 4 (n = 3, µ = 0.20, IQR = 0.20–0.21) |
LNA | 0.18 | 0.15–0.21 | • Severe stroke (n = 21, µ = 0.19, IQR = 0.18–0.20) • Expanded disability status scale ≥ 4 (n = 9, µ = 0.19, IQR = 0.18–0.21) • Alzheimer’s disease/dementia (n = 7, µ = 0.18, IQR = 0.16–0.18) • Terminal breast cancer (n = 5, µ = 0.19, IQR = 0.19–0.19) • Brain hemorrhage (n = 5, µ = 0.17, IQR = 0.15–0.18) • Amputation (n = 5, µ = 0.20, IQR = 0.19–0.20) • Heart failure (n = 4, µ = 0.20, IQR = 0.19–0.20) • Spinal cord compression (n = 4, µ = 0.19, IQR = 0.19–0.20) • Hepatocellular carcinoma (n = 3, µ = 0.20, IQR = 0.20–0.21) • Arthritis progression (n = 3, µ = 0.19, IQR = 0.18–0.20) |