Estimating the minimally important difference for the EQ-5D-5L and EORTC QLQ-C30 in cancer

Table 5 EQ-5D-5L utility index MID using linear regression models and distribution -based MCD

	Linear Regression Model		Linear Regression Model (baseline EQ-5D-5L utility index score)		Distribution-based Approach (MCD)
Anchors	Improve	Deteriorate	Improve	Deteriorate	0.5	0.3	SEM
EQ-VAS	0.06 (0.41)	-0.04^a (-0.27)	0.05^{a, b} (0.37)	-0.04^a (-0.26)	0.07	0.04	0.06
Q29 (QLQ-C30 overall health)	0.03^a (0.23)	-0.03^a (-0.21)	0.03^a (0.23)	-0.03^a (-0.21)
Q30 (QLQ-C30 quality of life)	0.01 (0.09)	-0.04^a (-0.25)	0.01 (0.08)	-0.03^{a, b} (-0.25)
Weighted EQ-5D-5L MID	0.03 (0.25)	-0.03 (-0.25)	0.03 (0.23)	-0.03 (-0.24)

EQ-VAS, EuroQol Visual Analogue Scale; MID, minimally important difference; MCD, minimal detectable change; Bold figures reflect effect size (ES)
^aMID change vs. no change is statistically significant at 0.01
^bBaseline EQ-5D-5L utility significant

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