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Table 6 EQ-VAS MID using linear regression models and distribution -based MCD

From: Estimating the minimally important difference for the EQ-5D-5L and EORTC QLQ-C30 in cancer

 

Linear Regression

Model

Linear Regression Model (baseline EQ-5D-5L utility)

Distribution-based Approach (MCD)

Anchors

Improve

Deteriorate

Improve

Deteriorate

0.5

0.3

SEM

Q29 (QLQ-C30 overall health)

6.00

(0.40)

-5.00

(0.30)

6.00a

(0.40)

-5.00a

(-0.30)

8.00

5.00

7.00

Q30 (QLQ-C30 quality of life)

5.00a

(0.3)

-4.00a

(0.3)

4.00a

(0.30)

-4.00

(0.20)

   

Weighted

EQ-VAS MID

5.00

(0.30)

-5.00

(0.30)

5.00

(0.30)

-5.00

(-0.30)

   
  1. EQ-VAS, EuroQol Visual Analogue Scale; MID, minimally important difference; MCD, minimal detectable change; QLQ-C30, Quality of life Questionnaire Core 30
  2. Bold figures reflect effect size (ES)
  3. aMID change vs. no change is statistically significant at 0.01