Skip to main content

Table 7 Base-case EORTC QLQ-C30 MID estimates

From: Estimating the minimally important difference for the EQ-5D-5L and EORTC QLQ-C30 in cancer

 

Linear Regression model

Distribution-based approach (MCD)

Scale

Improve

Deteriorate

0.3

0.5

SEM

PFa

2.75 to 6.37

(3.64)

-6.58 to -3.01

(-4.28)

5.37 4

7.59

7.59

RFa

5.39 to 9.25

(6.31)

-8.12 to -6.43

(-7.11)

13.63

8.2

11.57

EF

4.39 to 5.08

(4.65)

-4.96 to -1.96

(-3.41)

10.72

6.43

9.09

CF

2.18 to 2.68

(2.44)b

-3.13 to -2.90

(-3.03)

10.11

6.06

8.58

SF

4.98 to 5.81

(5.41)

-7.04 to -4.12

(-5.56)

12.93

7.77

10.97

FAa

4.95 to 7.23

(5.76)

-8.27 to -6.47

(-6.93)

11.48

6.89

9.76

NV

1.16 to 2.71

(1.86)

-2.26 to -2.12

(-2.19)

5.86

3.52

4.98

PA

3.39 to 5.37

(4.31)

-7.36 to -5.48

(-6.54)

12

7.2

10.18

DY

0.25 to 2.11

(1.39)b

-4.48 to -3.29

(-4.08)

10.49

6.29

8.9

SL

4.43 to 7.01

(5.63)

-6.18 to -5.05

(-5.70)

14.64

8.78

12.42

AP

3.00 to 4.85

(3.84)

-4.87 to -2.32

(-3.42)

11.71

7.03

9.94

  1. AP, appetite loss; CF, cognitive functioning; DY, dyspnoea; ECOG, Eastern Cooperative Oncology Group; EF, emotional functioning; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of life Questionnaire Core 30; EQ-VAS, EuroQol Visual Analogue Scale; FA, fatigue; MID, minimally important difference; MCD, minimal detectable change; NV, nausea/vomiting; PA, pain; PF, physical function; QL, global health status/quality of life; RF, role functioning; SF, social functioning; SL, insomnia
  2. Bold figures reflect EORTC QLQ-C30 subscale weighted MID estimates
  3. aECOG anchor available for estimation for these subscales
  4. bFailed to meet the Cohen’s criteria, a true MID estimate effect size is required to be between ≥ 0.2 and ≤ 0.8