A time trade-off study in the UK, Canada and the US to estimate utilities associated with the treatment of haemophilia

Table 5 Utility gain/disutility associated with aspects of haemophilia treatment elicited for caregivers of children with haemophilia

	UK			Canada			US
	N	Utility	95% CI	N	Utility	95% CI	N	Utility	95% CI
Monthly vs weekly SC injections w. prefilled pen	226	0.018*	0.007; 0.029	201	-0.001	-0.011; 0.009	183	0.004	-0.010; 0.016
SC injections w. prefilled pen vs syringe once a month	222	0.042*	0.030; 0.055	173	0.043*	0.029; 0.057	170	0.017*	0.001; 0.033
SC injections w. prefilled pen vs double dose w. syringe once a month	222	0.053*	0.038; 0.068	173	0.060*	0.042; 0.077	170	0.043*	0.026; 0.060
Monthly SC injections w. prefilled pen vs weekly IV infusions	228	0.040*	0.027; 0.053	188	0.048*	0.031; 0.065	146	0.013	-0.006; 0.031
Monthly SC injections w. prefilled pen vs weekly SC injections w. syringe	222	0.044*	0.032; 0.057	173	0.039*	0.026; 0.054	170	0.028*	0.012; 0.045
Avoid injection site reactions	222	0.011*	0.002; 0.021	173	0.015*	0.002; 0.028	170	0.013	-0.004; 0.031

ISSN: 1477-7525