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Table 1 Study characteristics at the micro-level (sorted by medical domain)

From: The use of patient-reported outcome measures to improve patient-related outcomes – a systematic review

Author (year)

Domain

Patients

Number of patients (I = Intervention, C = Control)

PROM(s) used (GEN = generic, DS = disease-specific)

Overall impact

Quality of study

Decision-aid

Jayakumar (2021)

Orthopedics

Considering knee replacement for OA

I:69; C:60

KOOS-JR (DS), PROMIS Global 10 (GEN)

 + 

Moderate

Bansback (2022)

Orthopedics

Considering knee replacement for OA

I:82; C:81

EQ-5D-5L (GEN)

 + 

Weak

Volkmann (2015)

Rheumatology

Considering knee replacement for OA

I:111; C:NA

WOMAC (DS)

 + 

Moderate

Feedback to patient

Ngo (2022)

Gyneacology

Pregnant women

I:89; C:103

PUQE (DS)

 ~ 

Moderate

Rogers (2021)

Oncology

Head-neck cancer, curatively treated

I:140; C:148

PCI Head Neck Cancer (DS)

 + 

Moderate

Steele Gray (2021)

Primary care

Elderly

I:23; C:21

PROMIS Global Health Scale (GEN), Pain Interference (DS), HAQ (GEN)

 ~ 

Weak

Berdal (2023)

Rehabilitation

Rheumatic or musculoskeletal diseases

I:168;C:206

PSFS (DS), EQ-5D-5L (GEN), EQ VAS (GEN), 30 s sit-to-stand test

 ~ 

Moderate

Gossec (2016)

Rheumatology

Reumatoid arthritis

I:159; C:161

RAPID-3/HAQ2 (GEN), RAID (DS), symptoms as free text

 ~ 

Moderate

Feedback to provider

Hadjistavropoulos (2009)

Community care

Elderly, with complex medical problems

I:88; C:56

Pain Assessment Battery (DS), GPM (DS), GDS short form (DS), pain drawing

 ~ 

Weak

Almario (2016)

Gastroenterology

Gastrointestinal disease

I:217; C:154

PROMIS Gastrointestinal (DS)

 ~ 

Moderate

Kjaer (2016)

Oncology

Head-neck cancer, finished treatment

I:132; C:134

HADS (DS), symptoms relevant to head-neck cancer survivors

 + 

Weak

Velikova (2004)

Oncology

Any cancer, commencing treatment

I:144, 70; C:72

EORTC-QLQ-C30 (DS), and HADS (DS)

 + 

Weak

Detmar (2002)

Oncology

Any cancer, undergoing palliative chemotherapy

I:114; C:100

EORTC-QLQ-C30 (DS)

 ~ 

Weak

Rosenbloom (2007)

Oncology

Advanced breast, lung or colorectal cancer

I:71, 73; C:69

FACT-G (DS), including relevant cancer-type subscale

 ~ 

Strong

Hilarius (2008)

Oncology

Any cancer, undergoing adjuvant or palliative chemotherapy

I:111; C:108

EORTC-QLQ-C30 (DS), including relevant cancer-type (breast (QLQ-BR23), colorectal (QLQ- CR38), or lung cancer (QLQ-LC13))

 ~ 

Strong

Barbera (2015)

Oncology

Stage I–III breast cancer, received adjuvant chemotherapy

I:2541; C:5818

ESAS (DS)

 + 

Strong

Patel (2022)

Oncology

Advanced cancer

I:64; C:64

ESAS (DS)

 + 

Strong

Skovlund (2021)

Oncology

Metastic melanoma

I:137; C:142

EORTC-QLQ-C30 (DS), HADS (DS)

 + 

Weak

Ackermans (2017)

Orthopedics

Hip or knee OA

I:72; C:70

HOOS-PS/KOOS-PS (DS), NRS Pain (DS)

 + 

Strong

Holm (2020)

Orthopedics

Hip or knee OA

I:6245; C:N/A

NRS pain (DS), HOOS/KOOS (DS), EQ-5D (GEN), PSFS (DS), physical activity (DS), OA-QI (DS), ASES (DS)

 + 

Strong

De Wit (2008)

Pediatrics

Diabetes

I:46; C:45

PedsQL (GEN), Generic and Diabetes module (DS)

 + 

Moderate

Fihn (2004)

Primary care

Veterans

I:5801; C:3218

SF-36 (GEN), Seattle Outpatient Satisfaction Questionnaire (PREM), 1 of 6 disease-specific questionnaires (Seattle Angina, Seattle Obstructive Lung Disease, Drinking Practices, Seattle Diabetes, Seattle Hypertension, HSCL)

 ~ 

Weak

Kroenke (2018)

Primary care

Visiting for any reason

I:151; C:149

SPADE symptoms (GEN)

 ~ 

Moderate

Reiber (2004)

Primary care

Veterans

I:3701; C:2020

Seattle Diabetes Questionnaire, SF-36 (GEN), SOSQ (PREM)

 ~ 

Weak

Richardson (2008)

Primary care

Elderly

I:134; C:131

Self Report Task Modification and Disability Scale (DS), HUI (GEN), SF-36 (GEN), several physical and functional performance measures

 + 

Moderate

Santana (2010)

Pulmonary medicine

Pre- and post-lung transplant

I:108; C:105

HUI2/3 (GEN)

 ~ 

Moderate

Monitoring

Davidson (2010)

Cardiology

Myocardial infarction

I:80; C:77

PHQ-9 (DS)

 + 

Moderate

de Jong (2017)

Gastroenterology

IBS

I:465; C:444

Monitor IBD At Home (DS)

 + 

Moderate

Berinstein (2022)

Gastroenterology

IBS

I:100; C:105

CD-PRO (DS), UC-PRO (DS)

 + 

Strong

Cross (2019)

Gastroenterology

IBS

I:115, 116; C:117

HBI (DS), SSCAI (DS)

 + 

Moderate

Pooni (2023)

General surgery

Colorectal surgery

I:128; C:125

QoR-15 (DS)

 + 

Strong

Girgis (2009)

Oncology

Non-localized breast and colorectal cancer

I:120, 119; C:117

HADS (DS), EORTC-QLQ-C30 (DS), SCNS short form (DS), selected items from the NA-ACP (DS)

 ~ 

Moderate

Cooley (2022)

Oncology

Lung cancer

I:89; C:91

PHQ-9 (DS), SDS (DS), FACT-G (DS), AUDIT (DS), MSAS (DS)

 ~ 

Weak

Price (2023)

Oncology

Cancer patients with depression

I:165; C:NA

PHQ-9 (DS) and GAD-2 (DS)

 + 

Weak

Livanainen (2023)

Oncology

Colorectal cancer, undergoing chemotherapy

I:36; C:35

NCTCAE (DS)

 ~ 

Weak

Basch (2016)

Oncology

Metastatic breast, genitourinary, gynecologic or lung cancer

I:441; C:325

NCTCAE (DS)

 + 

Moderate

Sharpe (2014)

Oncology

Cancer patients with depression

I:253; C:247

PHQ-9 (DS)

 + 

Weak

Patel (2020)

Oncology

Hematologic or advanced stage cancer

I:186; C:102

Edmonton Symptom Assessment Scale (DS)

 + 

Strong

Maguire (2021)

Oncology

Non-metastatic breast, colorectal, (non-)Hodgkin’s cancer, undergoing chemotherapy

I:415; C:414

DCTAQ (DS)

 + 

Strong

Epstein (2007)

Pediatrics

ADHD

I:162; C:215

CPRS (DS), CTRS (DS)

 ~ 

Moderate

Dobscha (2006)

Primary care

Moderate to severe depression

I:189; C:186

PHQ-9 (DS)

 + 

Strong

Balestrieri (2020)

Primary care

Depression

I:66; C:32

PHQ-9 (DS) and IDS-SR (DS)

 + 

Moderate

Dhingra (2021)

Primary care

Chronic pain

I:256; C:272

FPS (DS), SBIRT (DS), PHQ-2 (DS), BPI short form (DS), PROMIS Pain Interference short form (DS)

 ~ 

Weak

Katon (1996)

Primary care

Depression

I:77; C:76

BDI short form (DS)

 + 

Moderate

Katzelnick (2000)

Primary care

Depression

I:218; C:189

HAM-D (DS)

 + 

Moderate

Unützer (2002)

Primary care

Depression

I:218; C:189

PHQ-9 (DS)

 + 

Weak

Simon (2011)

Primary care

Depression

I:106; C:102

PHQ-9 (DS)

 + 

Weak

Katon (2004)

Primary care

Diabetes patients, with depression

I:164; C:165

PHQ-9 (DS)

 + 

Weak

Carola Pèrez (2021)

Psychiatry

Depression

I:84; C:83

PHQ-9 (DS)

 ~ 

Moderate

Tirelli (2020)

Reumatology

Juvenile Idiopathic Arthritis, subtype Enthesitis-Related Arthritis

I:54; C:98, 51

JADAS (DS), PROMIS physical function (DS), NRS pain (DS)

 ~ 

Moderate

Buckley (2020)

Rheumatology

Juvenile Idiopathic Arthritis

I:97; C:NA

JADAS (DS), PROMIS physical function (DS), NRS pain (DS)

 + 

Moderate

No feedback

Baker (2023)

Dermatology

Eczema

I:147; C:149

POEM (DS)

 + 

Moderate

McCambridge (2007)

General public

University students

I:217; C:204

AUDIT (DS)

 + 

Moderate

Jaensson (2017)

General surgery

Various types of day surgery

I:513; C:514

SwQoR (DS)

 + 

Strong

Screening

Frasure-Smith (1997)

Cardiology

Myocardial infarction

I:692; C:684

GHQ (DS)

 ~ 

Strong

Kronish (2020)

Cardiology

Myocardial infarction

I:499, 501; C:500

PHQ-8 (DS)

 ~ 

Weak

Allen (2011)

Community care

War veterans

I:97; C:NA

DASS (DS), AUDIT (DS)

 + 

Weak

van der Zee-van den Berg (2017)

Midwife care

Mothers who just gave birth

I:1843; C:1246

EPDS (DS)

 + 

Moderate

Ferrell (2021)

Oncology

Palliative cancer, undergoing a therapeutic clinical trial

I:239; C:240

Distress Thermometer (DS), FACT-G (DS)

 + 

Weak

Shyu (2013)

Orthopedic and trauma surgery

Hip fracture patients

I:99; C:101, 99

GDS short form (DS)

 + 

Strong

Mallen (2017)

Primary care

Hip or knee osteoarthritis patients

I:1339; C:703

GAD-2 (DS), PHQ-2 (DS), NRS pain (DS)

-

Moderate

Fortmann (2020)

Primary care

Diabetes patients

I:236;C:239

PHQ-9 (DS)

 + 

Moderate

Rollman (2021)

Cardiology

Heart failure

I:251; C:252, 126

PHQ-2 and -9 (DS)

 + 

Moderate

Regueiro (2019)

Gastroenterology

IBS

I:322; C:NA

Harvey-Bradshaw Index (DS) for CD or Ulcerative Colitis Activity Index for UC, Short Inflammatory Bowel Disease questionnaire (DS), PHQ-9 (DS), GAD-7 (DS)

 + 

Moderate

Howell (2020)

Oncology

Various types of cancer

I:13,260, 10,875; C:57,594, 48,068

ESAS (DS), DART (DS), BPI (DS), CFS (DS), GAD (DS), PHQ (DS), occasionally the CPC (DS) or SDI (DS)

 + 

Strong

Wylde (2022)

Orthopedics

Received knee replacement surgery

I:242; C:121

BPI (DS), HADS (DS), PainDETECT (DS), Douleur Neuropathique 4 (DS)

 + 

Weak

Buxton (2012)

Primary care

Low income and uninsured

I:36; C:81

SF-12 (GEN), AUDIT (DS), PHQ-9 (DS)

 ~ 

Moderate

Wu (2018)

Primary care

Diabetes type 2

I:366, 380; C:341

PHQ -2 and/or -9 (DS)

 + 

Strong

  1. Studies are categorized according to the mechanism applied. Additional study characteristics, full quality assessment and all extracted outcomes can be found in Supplementary Material 3, Table 1 to 3
  2. ADHD Attention Deficit Hyperactivity Disorder, ASES Arthritis Self-Efficacy Scale, AUDIT Alcohol Use Disorders Identification Test, BDI Beck Depression Inventory, BPI Brief Pain Inventory, CD-PRO Crohn’s Disease PRO, CFS Cancer Fatigue Scale, COOP Primary Care Cooperative Information Project, CPC Canadian Problem Checklist, CPRS Conners Parent Rating Scale, CTRS Conners Teachers Rating Scale, DART Distress Assessment Response Tool, DASS Depression Anxiety Stress Scales, DCTAQ Daily Chemotherapy Toxicity Self-Assessment Questionnaire, EORTC-QLQ-C30 The European Organization for Research and Treatment of Cancer quality of life questionnaire, EPDS Edinburgh Postnatal Depression Scale, EQ-5D-5L Five-level version of the EQ-5D, ESAS Edmonton Symptom Assessment System, FACT-G Functional Assessment of Cancer Therapy—General, FPS Faces Pain Scale, GAD Generalized Anxiety Disorder, GDS Geriatric Depression Scale, GHQ General Health Questionnaire, GPM Geriatric Pain Measure, HADS Hospital Anxiety and Depression Scale, HAM-D Hamilton Depression Rating Scale, HAQ Health Assessment Questionnaire, HBI Harvey-Bradshaw Index, HOOS-PS Hip disability and Osteoarthritis Outcome Score – Physical Function, HSCL Hopkins Symptom Checklist, HUI Health Utilities Index Mark, IBS Inflammatory Bowel Disease, IDS-SR Inventory of Depressive Symptomatology – Self Rated, JADAS Clinical Juvenile Arthritis Disease Activity Score, KOOS-JR Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, KOOS-PS Knee disability and Osteoarthritis Outcome Score – Physical Function, MSAS Memorial Symptom Assessment Scale, NA-ACP Needs Assessment for Advanced Cancer Patient Questionnaire, NCTCAE National Cancer Institute's Common Terminology Criteria for Adverse Events, NRS Numerical Rating Scale, OA-QI OsteoArthritis Quality Indicator Questionnaire, OHS Oxford Hip Score, OKS Oxford Knee Score, PCI Patient Concerns Inventory, PedsQL Pediatric Quality of Life Inventory, PHQ Patient Health Questionnaire, POEM Patient Oriented Eczema Measure, PREMs patient-reported experience measures, PROMs patient-reported outcome measures, PROMIS Patient-Reported Outcomes Measurement Information System, PSFS Patient Specific Functional Scale, PUQE Pregnancy Unique Quantification of Emesis, QoR-15 Quality of Recovery questionnaire, RAID Reumatoid Arhritis Impact of Disease, RAPID-3/HAQ2 RAPID3 Health Assessment Questionnaire, SBIRT Screening, Brief Intervention, and Referral to Treatment questionnaire, SCNS Supportive Care Needs Survey, SDI Social Difficulties Inventory, SDS Symptom Distress Scale, SF-36 Short Form Health Survey, SOSQ Seattle Outpatient Satisfaction Questionnaire, SPADE Sleep, pain, anxiety, depression, and low energy/fatigue, SSCAI Simple Clinical Colitis Activity Index, SwQoR Swedish Quality of Recovery Scale, UU-PRO Ulcerative Colitis PRO, VAS Visual Analogue Scale, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index