Does adjuvant chemotherapy result in poorer health-related quality of life among colorectal cancer patients? A longitudinal multisite observational study in Singapore

Lau, Jerrald; Peh, Cherie Hui; Ng, Alyssa; Koh, Wei-Ling; Luo, Nan; Tan, Ker-Kan

doi:10.1186/s12955-025-02363-1

Table 2 Mean GQOL and functioning scores across study timepoints between patients in the AC and No AC groups

From: Does adjuvant chemotherapy result in poorer health-related quality of life among colorectal cancer patients? A longitudinal multisite observational study in Singapore

	AC (N = 102)			No AC (N= 149)			p
	Mean	SD	Missing (%)	Mean	SD	Missing (%)
GQOL
Baseline	68.11	20.06	-	68.02	20.83	-	0.97
Pre-discharge	57.58	21.72	9.80	60.71	21.88	35.57	0.34
1-month	66.76	15.47	4.90	67.19	22.11	19.46	0.87
3-month	66.48	16.09	8.82	73.99	17.67	28.19	< 0.05*
6-month	72.75	18.61	14.71	73.93	18.47	27.52	0.67
9-month	71.08	16.32	16.67	75.89	18.31	33.56	0.07
12-month	72.09	16.07	16.67	73.08	19.29	36.24	0.72
Physical functioning
Baseline	93.06	11.52	-	88.44	18.88	-	< 0.05*
Pre-discharge	54.42	28.08	11.76	60.07	24.72	35.57	0.16
1-month	81.01	18.78	5.88	74.53	23.72	18.79	< 0.05*
3-month	86.22	14.85	8.82	83.43	79.40	26.85	0.29
6-month	90.04	13.90	14.71	87.00	18.00	27.52	0.21
9-month	87.47	16.80	16.67	87.23	18.23	34.23	0.93
12-month	90.57	14.40	17.65	85.78	20.49	38.26	0.08
Role functioning
Baseline	92.52	19.75	-	90.96	20.94	-	0.57
Pre-discharge	44.25	36.46	10.78	52.20	34.18	35.57	0.14
1-month	75.69	26.65	4.90	71.32	34.10	18.79	0.37
3-month	82.59	25.47	8.82	82.67	26.66	26.85	0.98
6-month	88.43	21.52	14.71	86.96	20.49	27.52	0.64
9-month	85.74	22.86	16.67	88.83	21.50	33.56	0.36
12-month	91.97	16.54	16.67	88.15	22.93	36.91	0.21
Emotional Functioning
Baseline	80.78	20.67	-	82.56	19.99	-	0.51
Pre-discharge	72.47	28.10	8.82	80.59	23.86	35.57	< 0.05*
1-month	83.51	21.28	4.90	84.61	22.67	18.79	0.72
3-month	84.26	19.37	8.82	89.85	16.77	26.85	< 0.05*
6-month	87.65	17.61	14.71	91.17	14.18	27.52	0.13
9-month	88.35	16.36	16.67	92.20	13.26	33.56	0.08
12-month	88.65	14.47	16.67	91.67	13.21	36.24	0.15
Cognitive functioning
Baseline	93.20	11.68	-	93.80	11.61	-	0.70
Pre-discharge	82.58	21.87	9.80	84.80	22.86	35.57	0.51
1-month	93.37	16.32	4.90	89.94	19.11	20.13	0.17
3-month	92.04	13.27	8.82	93.73	12.44	26.85	0.36
6-month	92.55	12.73	14.71	94.17	11.70	28.19	0.37
9-month	90.56	15.87	16.67	93.79	13.38	33.56	0.14
12-month	92.07	13.41	17.65	92.12	14.77	36.24	0.98
Social functioning
Baseline	87.76	22.01	-	88.24	21.08	-	0.87
Pre-discharge	63.30	31.10	8.82	74.73	28.26	35.57	< 0.05*
1-month	82.97	25.89	4.90	77.63	30.85	18.79	0.19
3-month	84.44	24.07	8.82	85.97	22.82	26.85	0.65
6-month	86.67	22.83	14.71	90.10	19.17	27.52	0.27
9-month	87.35	22.93	16.67	94.33	14.98	33.56	< 0.05*
12-month	90.96	18.09	16.67	91.76	20.24	36.24	0.79

^* represents p < 0.05

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