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  1. Dental disease and treatment experience can negatively affect the oral health related quality of life (OHRQL) of preschool aged children and their caregivers. Currently no valid and reliable instrument is avai...

    Authors: Bhavna Talekar Pahel, R Gary Rozier and Gary D Slade
    Citation: Health and Quality of Life Outcomes 2007 5:6
    Content type: Research Published on:

  2. Health-related quality of life (HR-QOL) is a relevant and quantifiable outcome of care. We implemented HR-QOL assessment at all primary care visits at UCSD Owen Clinic using EQ-5D. The study aim was to estimat...

    Authors: William C Mathews and Susanne May
    Citation: Health and Quality of Life Outcomes 2007 5:5
    Content type: Research Published on:

  3. Quality of life (QoL) outcomes are useful in the assessment of physical, mental and social well-being and for informed healthcare decision making. However, few studies have evaluated QoL issues among Asian chi...

    Authors: Hwee-Lin Wee, Ulrike Ravens-Sieberer, Michael Erhart and Shu-Chuen Li
    Citation: Health and Quality of Life Outcomes 2007 5:4
    Content type: Research Published on:

  4. The last three decades have seen a dramatic rise in the implementation of screening programmes for cancer in industrialised countries. However, in contrast to screening for infectious diseases, most cancer scr...

    Authors: John Brodersen, Stephen P McKenna, Lynda C Doward and Hanne Thorsen
    Citation: Health and Quality of Life Outcomes 2007 5:3
    Content type: Commentary Published on:

  5. Health-related quality of life (HRQOL) measurement has emerged as an important health outcome in clinical trials, clinical practice improvement strategies, and healthcare services research and evaluation. Whil...

    Authors: James W Varni, Christine A Limbers and Tasha M Burwinkle
    Citation: Health and Quality of Life Outcomes 2007 5:2
    Content type: Research Published on:

  6. The last decade has evidenced a dramatic increase in the development and utilization of pediatric health-related quality of life (HRQOL) measures in an effort to improve pediatric patient health and well-being...

    Authors: James W Varni, Christine A Limbers and Tasha M Burwinkle
    Citation: Health and Quality of Life Outcomes 2007 5:1
    Content type: Research Published on:

  8. Interferon-beta (IFN-β) shows beneficial effect on the course of multiple sclerosis (MS), nevertheless its route and frequency of administration and side effects might impact negatively the quality of life (Qo...

    Authors: Isabella Laura Simone, Antonia Ceccarelli, Carla Tortorella, Alessandra Bellacosa, Fabio Pellegrini, Immacolata Plasmati, Maria Fara De Caro, Mariangela Lopez, Francesco Girolamo and Paolo Livrea
    Citation: Health and Quality of Life Outcomes 2006 4:96
    Content type: Research Published on:

  9. Although non-communicable and chronic disease now accounts for 47% of the global burden of disease, little is known of the everyday experiences and social aspects of disability and disablement in middle and lo...

    Authors: RoseAnne Misajon, Lenore Manderson, Julie F Pallant, Zaliha Omar, Elizabeth Bennett and Rameezan Begam Abdul Rahim
    Citation: Health and Quality of Life Outcomes 2006 4:95
    Content type: Research Published on:

  10. Combining outcomes and the use of standardized effect measures such as effect size and standardized response mean across instruments allows more comprehensive meta-analyses and should avoid selection bias. How...

    Authors: Milo A Puhan, Irene Soesilo, Gordon H Guyatt and Holger J Schünemann
    Citation: Health and Quality of Life Outcomes 2006 4:94
    Content type: Research Published on:

  11. To characterize ease in discussing death (EID) and its influence on health valuation in a multi-ethnic Asian population and to determine the acceptability of various descriptors of death and "pits"/"all-worst"...

    Authors: Hwee-Lin Wee, Shu-Chuen Li, Feng Xie, Xu-Hao Zhang, Nan Luo, Yin-Bun Cheung, David Machin, Kok-Yong Fong and Julian Thumboo
    Citation: Health and Quality of Life Outcomes 2006 4:93
    Content type: Research Published on:

  12. This paper evaluates psychometric properties of a recently developed measure focusing on the health-related quality of life (HRQL) of long-term cancer survivors, the Quality of Life in Adult Survivors scale (Q...

    Authors: Nancy E Avis, Edward Ip and Kristie Long Foley
    Citation: Health and Quality of Life Outcomes 2006 4:92
    Content type: Research Published on:

  13. There is a paucity of research about health-related quality of life (HRQL) among adolescents, as studies have to a large extent focused on adults. The main aim was to provide information for future studies in ...

    Authors: Anna Jörngården, Lena Wettergen and Louise von Essen
    Citation: Health and Quality of Life Outcomes 2006 4:91
    Content type: Research Published on:

  15. Responsiveness, or sensitivity to clinical change, is an important consideration in selection of a health-related quality of life (HRQL) measure for trials or clinical applications. Many approaches can be used...

    Authors: Dean T Eurich, Jeffrey A Johnson, Kimberly J Reid and John A Spertus
    Citation: Health and Quality of Life Outcomes 2006 4:89
    Content type: Research Published on:

  16. The PGWBI is a 22-item health-related Quality of Life (HRQoL) questionnaire developed in US which produces a self-perceived evaluation of psychological well-being expressed by a summary score. The PGWBI has be...

    Authors: Enzo Grossi, Nicola Groth, Paola Mosconi, Renata Cerutti, Fabio Pace, Angelo Compare and Giovanni Apolone
    Citation: Health and Quality of Life Outcomes 2006 4:88
    Content type: Research Published on:

  17. To determine the clinimetric properties of two questionnaires assessing symptoms (Symptom Severity Scale) and physical functioning (hand and finger function subscale of the AIMS2) in a Dutch primary care popul...

    Authors: Marinda N Spies-Dorgelo, Caroline B Terwee, Wim AB Stalman and Daniëlle AWM van der Windt
    Citation: Health and Quality of Life Outcomes 2006 4:87
    Content type: Research Published on:

  18. Recent research has suggested that chronic dry mouth affects the day-to-day lives of older people living in institutions. The condition has usually been considered to be a feature of old age, but recent work b...

    Authors: W Murray Thomson, Herenia P Lawrence, Jonathan M Broadbent and Richie Poulton
    Citation: Health and Quality of Life Outcomes 2006 4:86
    Content type: Research Published on:

  20. Research on quality and satisfaction with care during palliative chemotherapy in oncology patients has been limited. The objective was to assess the association between patient's satisfaction with care and sym...

    Authors: Vivian E von Gruenigen, Jessica R Hutchins, Anne Marie Reidy, Heidi E Gibbons, Barbara J Daly, Elisa M Eldermire and Nancy L Fusco
    Citation: Health and Quality of Life Outcomes 2006 4:84
    Content type: Research Published on:

  21. The aims of the study were to assess the impact of both positive (PA) and negative affect (NA) on self-reported oral health-related quality of life and to determine the effect of including affectivity on the r...

    Authors: David S Brennan, Kiran A Singh, A John Spencer and Kaye F Roberts-Thomson
    Citation: Health and Quality of Life Outcomes 2006 4:83
    Content type: Research Published on:

  22. Screening asymptomatic individuals for neoplasia can have adverse consequences on quality of life. Colon cancer screening is widespread but the quality of life (QOL) consequences are unknown. This study determ...

    Authors: Doug Taupin, Sharon L Chambers, Mike Corbett and Bruce Shadbolt
    Citation: Health and Quality of Life Outcomes 2006 4:82
    Content type: Research Published on:

  23. In Canada, the incidence of Fetal Alcohol Spectrum Disorder (FASD) has been estimated to be 1 in 100 live births. Caused by prenatal exposure to alcohol, FASD is the leading cause of neuro-developmental disabi...

    Authors: Brenda C Stade, Bonnie Stevens, Wendy J Ungar, Joseph Beyene and Gideon Koren
    Citation: Health and Quality of Life Outcomes 2006 4:81
    Content type: Research Published on:

  24. Patient-reported measures can be used to examine whether drug differences other than clinical efficacy have an impact on outcomes that may be important to patients. Although exenatide and insulin glargine appe...

    Authors: Kristina Secnik Boye, Louis S Matza, Alan Oglesby, Karen Malley, Sunny Kim, Risa P Hayes and Robert Brodows
    Citation: Health and Quality of Life Outcomes 2006 4:80
    Content type: Research Published on:

  27. The SF-36 has been used in a number of previous studies that have investigated the health status of childhood cancer survivors, but it never has been evaluated regarding data quality, scaling assumptions, and ...

    Authors: Raoul C Reulen, Maurice P Zeegers, Crispin Jenkinson, Emma R Lancashire, David L Winter, Meriel E Jenney and Mike M Hawkins
    Citation: Health and Quality of Life Outcomes 2006 4:77
    Content type: Research Published on:

  28. Investigations of the structure of psychological well-being items are useful for advancing knowledge of what dimensions define psychological well-being in practice. Ryff has proposed a multidimensional model o...

    Authors: Rosemary A Abbott, George B Ploubidis, Felicia A Huppert, Diana Kuh, Michael EJ Wadsworth and Tim J Croudace
    Citation: Health and Quality of Life Outcomes 2006 4:76
    Content type: Research Published on:

  29. The PedsQL™ Present Functioning Visual Analogue Scales (PedsQL™ VAS) were designed as an ecological momentary assessment (EMA) instrument to rapidly measure present or at-the-moment functioning in children and...

    Authors: Sandra A Sherman, Sarajane Eisen, Tasha M Burwinkle and James W Varni
    Citation: Health and Quality of Life Outcomes 2006 4:75
    Content type: Research Published on:

  30. If decisions on health care spending are to be as rational and objective as possible, knowledge on cost-effectiveness of routine care is essential. Our aim, therefore, was to evaluate the cost-utility of routi...

    Authors: Pirjo Räsänen, Kari Krootila, Harri Sintonen, Tiina Leivo, Anna-Maija Koivisto, Olli-Pekka Ryynänen, Marja Blom and Risto P Roine
    Citation: Health and Quality of Life Outcomes 2006 4:74
    Content type: Research Published on:

  31. To assess the literature for the impact of iron overload and infusion Iron Chelation Therapy (ICT) on patients' quality of life (QoL), and the availability of QoL instruments for patients undergoing infusion I...

    Authors: Linda Abetz, Jean-Francois Baladi, Paula Jones and Diana Rofail
    Citation: Health and Quality of Life Outcomes 2006 4:73
    Content type: Research Published on:

  32. The influence of gender on the expression of COPD has received limited attention. Quality of Life (QoL) has become an important outcome in COPD patients. The aim of our study was to explore factors contributin...

    Authors: Juan P de Torres, Ciro Casanova, Concepción Hernández, Juan Abreu, Angela Montejo de Garcini, Armando Aguirre-Jaime and Bartolome R Celli
    Citation: Health and Quality of Life Outcomes 2006 4:72
    Content type: Research Published on:

  33. Patient-reported outcome (PROs) measures are being used more frequently in investigational studies of treatments for moderate to severe plaque psoriasis. The objective of this study was to examine the relation...

    Authors: Richard Shikiar, Mary Kaye Willian, Martin M Okun, Christine S Thompson and Dennis A Revicki
    Citation: Health and Quality of Life Outcomes 2006 4:71
    Content type: Research Published on:

  34. Patient reported outcomes provide the patient's perspective on the effectiveness of treatment. The draft Food and Drug Administration guidance on patient reported outcomes for labeling and promotional claims r...

    Authors: Dennis A Revicki, David Cella, Ron D Hays, Jeff A Sloan, William R Lenderking and Neil K Aaronson
    Citation: Health and Quality of Life Outcomes 2006 4:70
    Content type: Commentary Published on:

  35. The evaluation and use of patient reported outcome (PRO) measures requires detailed understanding of the meaning of the outcome of interest. The Food and Drug Administration (FDA) recently presented its draft ...

    Authors: Jan L Brożek, Gordon H Guyatt and Holger J Schünemann
    Citation: Health and Quality of Life Outcomes 2006 4:69
    Content type: Commentary Published on:

  36. Our objective was to test a brief, symptom index for advanced renal cell carcinoma, a disease affecting over 38,000 Americans each year and often diagnosed in late stages.

    Authors: David T Eton, David Cella, Jennifer Bacik and Robert J Motzer
    Citation: Health and Quality of Life Outcomes 2006 4:68
    Content type: Research Published on:

  37. The purpose of this review was to: (1) locate all exercise treatment studies of fibromyalgia (FM) patients from 1988 through 2005, (2) present in tabular format the key details of each study and (3) to provide...

    Authors: Kim Dupree Jones, Dianne Adams, Kerri Winters-Stone and Carol S Burckhardt
    Citation: Health and Quality of Life Outcomes 2006 4:67
    Content type: Review Published on:

  38. Measuring health-related quality of life (HRQOL) is important in arthritis and the SF-36v2 is the current state-of-the-art. It is only emerging how well the Centers for Disease Control and Prevention (CDC) HRQ...

    Authors: Thelma Mielenz, Elizabeth Jackson, Shannon Currey, Robert DeVellis and Leigh F Callahan
    Citation: Health and Quality of Life Outcomes 2006 4:66
    Content type: Research Published on:

  39. A recently published article by the Scientific Advisory Committee of the Medical Outcomes Trust presents guidelines for selecting and evaluating health status and health-related quality of life measures used i...

    Authors: Mark J Atkinson and Richard D Lennox
    Citation: Health and Quality of Life Outcomes 2006 4:65
    Content type: Commentary Published on:

  40. This proof of concept (POC) study was designed to evaluate the use of an Internet-based bulletin board technology to aid parallel cross-cultural development of thematic content for a new set of patient-reporte...

    Authors: Mark J Atkinson, Jan Lohs, Ilka Kuhagen, Julie Kaufman and Shamsu Bhaidani
    Citation: Health and Quality of Life Outcomes 2006 4:64
    Content type: Research Published on:

  41. Most studies on health-related quality of life (HRQOL) in children with cancer focussed on survivors. Only few studies have evaluated patients during ongoing oncological treatment. The aim of this study was a ...

    Authors: Markus A Landolt, Margarete Vollrath, Felix K Niggli, Hanspeter E Gnehm and Felix H Sennhauser
    Citation: Health and Quality of Life Outcomes 2006 4:63
    Content type: Research Published on:

  42. This article deals with the problem of interpreting health-related quality of life (HRQL) outcomes in clinical trials. First, we will briefly describe how dichotomization and item response theory can facilitat...

    Authors: Holger J Schünemann, Elie A Akl and Gordon H Guyatt
    Citation: Health and Quality of Life Outcomes 2006 4:62
    Content type: Commentary Published on:

  43. Health-Related Quality of Life (HRQOL) studies concerning children and adolescents are a growing field of research. The Pediatric Quality of Life Inventory (PedsQL™) is considered as a promising HRQOL instrume...

    Authors: Trude Reinfjell, Trond H Diseth, Marijke Veenstra and Arne Vikan
    Citation: Health and Quality of Life Outcomes 2006 4:61
    Content type: Research Published on:

  44. We evaluated how well physicians' global estimates of disease severity correspond to more specific physician-rated disease variables as well as patients' self-rated health and other patient variables.

    Authors: Kurt Kroenke, Kathleen W Wyrwich, William M Tierney, Ajit N Babu and Fredric D Wolinsky
    Citation: Health and Quality of Life Outcomes 2006 4:60
    Content type: Research Published on:

  45. The Multicenter Study of Hydroxyurea (HU) in Sickle Cell Anemia (MSH) previously showed that daily oral HU reduces painful sickle cell (SS) crises by 50% in patients with moderate to severe disease. The morbid...

    Authors: Samir K Ballas, Franca B Barton, Myron A Waclawiw, Paul Swerdlow, James R Eckman, Charles H Pegelow, Mabel Koshy, Bruce A Barton and Duane R Bonds
    Citation: Health and Quality of Life Outcomes 2006 4:59
    Content type: Research Published on:

  46. In situations where children are unable or unwilling to respond for themselves, measurement of quality of life (QOL) is often obtained by parent proxy-report. However the relationship between child self and pa...

    Authors: Joanne Cremeens, Christine Eiser and Mark Blades
    Citation: Health and Quality of Life Outcomes 2006 4:58
    Content type: Research Published on:

  47. Single item questions about self ratings of overall health status are widely used in both military and civilian surveys. Limited information is available to date that examines what relationships exist between ...

    Authors: Christopher K Haddock, Walker SC Poston, Sara A Pyle, Robert C Klesges, Mark W Vander Weg, Alan Peterson and Margaret Debon
    Citation: Health and Quality of Life Outcomes 2006 4:57
    Content type: Research Published on:

  48. The objective was to study whether a Kiswahili version of the OIDP (Oral Impacts on Daily Performance) inventory was valid and reliable for use in a population of older adults in urban and rural areas of Tanza...

    Authors: IA Kida, AN Åstrøm, GV Strand, JR Masalu and G Tsakos
    Citation: Health and Quality of Life Outcomes 2006 4:56
    Content type: Research Published on:

  49. To analyse the cross-diagnostic validity of the Functional Independence Measure (FIM™) motor items in patients with spinal cord injury, stroke and traumatic brain injury and the comparability of summed scores ...

    Authors: Å Lundgren-Nilsson, A Tennant, G Grimby and KS Sunnerhagen
    Citation: Health and Quality of Life Outcomes 2006 4:55
    Content type: Research Published on:

  50. Changes in scores on health status questionnaires are difficult to interpret. Several methods to determine minimally important changes (MICs) have been proposed which can broadly be divided in distribution-bas...

    Authors: Henrica C de Vet, Caroline B Terwee, Raymond W Ostelo, Heleen Beckerman, Dirk L Knol and Lex M Bouter
    Citation: Health and Quality of Life Outcomes 2006 4:54
    Content type: Commentary Published on:
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Health and Quality of Life Outcomes

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